The Coulter principle: Imaginary origins

The Coulter principle: Imaginary origins

IN the opening session of CYTO 2013 a spokeswoman for the Wallace H. Coulter Foundation summarized from the podium a story, styled as an urban legend true so far as was known, of Wallace Coulter working toward sizing pigment particles but finding his paint sample frozen. He then supposedly thought of the similar viscosity of paint and blood before first demonstrating the Coulter Principle using...

Coulter Principle Short Course

Coulter Principle Short Course

The Coulter Principle: Foundation of an Industry

Introduced in the mid-1950s, the Coulter Principle became the foundation of an industry responding to the need for automated cell-counting instruments. The industry developed in three acts, as Wallace H. Coulter and his brother Joseph R. Coulter, Jr., developed the simple idea of passing cells through a sensing aperture. In Act I, Wallace’s desire to automate the routine erythrocyte count led t...

The Coulter Principle for Outlier Detection in Highly Concentrated Solutions

This application note will benefit chemical and material manufacturers concerned about micron and submicron par ticle contamination. Outliers are a common problem in many industrial applications. Outliers can be defined as particles that are significantly larger or smaller than the main particle size distribution, but which occur in a much lower frequency than the main par ticle size. As a simp...